Aduino MEGA2560 or DUE Atmel SAM3X8E ARM Cortex-M3

Is it possible to replace an Arduino Mega 2560 with an Arduino Due (Atmel SAM3X8E ARM Cortex-M3)? I’ve noticed they are priced almost identically on AliExpress. What are the main implications of making this switch?

P.S. There is a DC Jack on the case. Should it be connected to the 12V rail on the main board or directly to the Arduino’s power input?

P.S.2 If I understand correctly, all sensors are powered via the Arduino’s 5V output, which is regulated by the onboard stabilizer. If the board is powered through USB, is there a risk of the stabilizer burning out, given that it also powers a servomotor in addition to the sensors? I am considering adding a linear regulator, such as the AMS1117, to power the 5V line for the Arduino, sensors, and the servo.